Бактериялық коллагеназалар - шолу мақаласы
Main Article Content
A. Kostanova
Ұлттық биотехнология орталығы, Қорғалжын тас жолы, 13/5, Астана қ., 010000, Қазақстан Республикасы
С.Сейфуллин атындағы Қазақ агротехникалық зерттеу университеті» КеАҚ, Жеңіс даңғылы, 62, Астана қ., 010011, Қазақстан Республикасы
kostanova@biocenter.kz
K. Baltin
National center for biotechnology, 13/5, Kurgalzhynskoye road, Astana, 010000, Kazakhstan
baltin@biocenter.kzAbstract
Бактериялық коллагеназалар - табиғи коллагенді қорыту қабілетіне байланысты жануарлар жасушаларының жасушадан тыс матрицасын бұзуға қатысатын металлопротеиназалар. Бұл ферменттер әртүрлі патогендік бактериялардың вируленттілігінің маңызды факторлары болып табылады. Дегенмен, ғылымда бұл ферменттердің дұрыс және нақты анықталған жіктелуіне қатысты консенсус жоқ және коллагеназаларды дұрыс анықтауға қатысты кең пікірталастар бар. Клостридиальды коллагеназалар бірінші болып сипатталды және жаңадан ашылған коллагенолитикалық ферменттерді салыстыру үшін анықтамалық ферменттер болып табылады. Бұл шолуда бактериялық коллагеназалар туралы ең соңғы деректерді ұсынып, бактериялық коллагеназалардың функционалды-құрылымдық әртүрлілігіне шолу жасалынды. Бұл ақуыздардың табиғаттағы молекулалық әртүрлілігі мен таралуының жалпы көрінісі де беріледі. Әр түрлі протеолитикалық белсенділіктің нақты аспектілері тиісті қолдану салаларында, негізінен биотехнологиялық процестер мен терапевтік мақсаттарда қарастырылады.
Article Details
Accepted 2025-11-13
Published 2024-12-30
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