Flavonoid composition of turmeric (Сurcuma longa) plant cultivated in Ebonyi state, Nigeria.
Main Article Content
Chukwuemeka Okoro
Department of Medical Biochemistry, David Umahi Federal University of Health Science, Uburu, Nigeria.
International Institute for Toxicology, Environmental & Occupational Health and Safety Research Uburu, Nigeria.
Department of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Abstract
Turmeric is one of the powerful gift of nature to man to treat diseases. The therapeutic and pharmacological uses of different bioactive components of turmeric are been slowly revealed. Flavonoid belongs to the human diet’s phenolic phytochemical compounds found in nature. This study analyzed the flavonoid composition of turmeric using standard method to reveal the presence and percentage composition of different flavonoids found in turmeric cultivated in Ebonyi State. The results revealed the presence of gallic acid (4.028), p-coumaric acid (1.464), ferrulic acid (7.949), rutin (5.88), quercetin (14.322) and kampferol (10.812 ppm). The high quantity of flavonoid in turmeric renders it a good plant in herbal medicine. This may account for the folkloric use of turmeric plant by miners in Ebonyi State.
Article Details
Accepted 2025-06-27
Published 2025-06-29
References
Bhowmik, D., Chiranjib, K.P., Kumar, S., Chandira, M., Jayakar, B. Turmeric: A Herbal and Traditional Medicine // Archives of Applied Science Research. – 2009. – Vol. 1(2). – P. 86-108.
Nasri, H., Sahinfard, N., Rafieian, M., Rafieian, S., Shirzad, M., Rafieian-kopaei, M. Turmeric: A spice with multifunctional medicinal properties // J. Herb. Med. Plarmacol. – 2014. – Vol. 3(1). – P. 5-8.
Ammon, H.P., Anazodo, M.I., Safayhi, H., Dhawan, B.N., Srimal, R.C. Curcumin: A potent inhibitor of leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMNL) // Planta Med. – 1992. – Vol. 58. – P. 226. https://doi.org/10.1055/s-2006-961438.
Rana, A.C., Gulliya B. Chemistry and Pharmacology of Flavonoids – A Review // Indian J. of Pharmaceutical Education and Research. – 2019. – Vol. 53(1). – P. 8-20. https://doi.org/10.5530/ijper.53.1.3.
Kumar S., Pandey A.K. Chemistry and biological activities of flavonoids: an overview // The Scientific World Journal. – 2013. – Vol. 2013. – Р. 1-16. https://doi.org/10.1155/2013/162750.
Carrillo-Martinez, E.J., Flores-Hernández, F.Y., Salazar-Montes, A.M., Nario-Chaidez, H.F., Hernández-Ortega, L.D. Quercetin, a Flavonoid with Great Pharmacological Capacity // Molecules. – 2024. – Vol. 29. – P. 1000. https://doi.org/10.3390/molecules29051000.
Zeb, A. Concept, mechanism, and applications of phenolic antioxidants in foods // J. Food Biochem. – 2020. – Vol. 44. – P. e13394. https://doi.org/10.1111/jfbc.13394.
Agati et al. Flavonoids – A Review // Indian J. of Pharmaceutical Education and Research. – 2012. – Vol. 53(1). – P. 8-20.
Pandey, R.P., Sohng, J.K. Genetics of Flavonoids. In: Natural Products-Phytochemistry, Botany, Metabolism of Alkaloids, Phenolics and Terpenes. Germany: Springer-Verlag Berlin Heidelberg. – 2013. – P. 1617-45.
Bigoniya P., Singh K. Ulcer protective potential of standardized hesperidin, a citrus flavonoid isolated from Citrus sinensis // Revista Brasileira de Farmacognosia. – 2014. – Vol. 24(3). – P. 330-340. https://doi.org/10.1016/j.bjp.2014.07.011.
Li, F., Liu, J., Tang, S., Yan, J., Chen, H., Li, D., Yan, X. Quercetin regulates inflammation, oxidative stress, apoptosis, and mitochondrial structure and function in H9C2 cells by promoting PVT1 expression // Acta Histochem. – 2021. – Vol. 123. – P. 151819. https://doi.org/10.1016/j.acthis.2021.151819.
Serafini, M., Peluso, I. Raguzzini A. Flavonoids as anti-inflammatory agents // Proceedings of the Nutrition Society. – 2010. – Vol. 69(3). – P. 273-278. https://doi.org/10.1017/S002966511000162X.
Noreen, Y., Serrano, G., Perera, P., Bohlin L. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis // Planta Medica. – 1998. – Vol. 64(06). – P. 520-524. https://doi.org/10.1055/s-2006-957506.
El-Marasy, S.A., Abdallah, H.M., El-Shenawy, S.M., El-Khatib, A.S., El-Shabrawy, O.A., Kenawy, S.A. Anti-depressant effect of hesperidin in diabetic rats // Canadian Journal of Physiology and Pharmacology. – 2014. – Vol. 92(11). – P. 945-952. https://doi.org/10.1139/cjpp-2014-0281.
Perez-Vizcaino, F., Duarte, J., Jimenez, R., Santos-Buelga, C., Osuna, A. Antihypertensive effects of the flavonoid quercetin // Pharmacological Reports. – 2009. – Vol. 61(1). – P. 67-75. https://doi.org/10.1016/s1734-1140(09)70008-8.
Djamil, R., Winarti, W., Zaidan, S., Abdillah, S. Antidiabetic Activity of Flavonoid from Binahong Leaves (Anredera cordifolia) Extract in Alloxan Induced Mice // Journal of Pharmacognosy and Natural Products. – 2017. – Vol. 3(2). – P. 1-4. https://doi.org/10.4172/2472-0992.1000139.
Hemmati, M., Mostafavi, S.E., Zarban, A., Hoshyar, R. Protective Effects of Quercetin on Hyperglycemia and Stress Proteins Expression in Rats with Streptozocin-Induced Diabetes // Mod. Care Journal. – 2018. – Vol. 15. – P. 8-14. https://doi.org/10.5812/modernc.64964.
Jacobsen, B.K., Knutsen, S.F., Fraser, G.E. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States) // Cancer Causes and Control. – 1998. – Vol. 9(6). – P. 553-557. https://doi.org/10.1023/a:1008819500080.
Juríková, T. Polyphenols and Their Mechanism of Action in Allergic Immune Response Immune Response // Glob. J. Allergy. – 2015. – Vol. 1. – P. 37-39. https://doi.org/10.17352/2455-8141.000008.
Mahboubi, A., Asgarpanah, J., Sadaghiyani, P.N., Faizi, M. Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases // BMC Complementary and Alternative Medicine. – 2015. – Vol. 15(1). – P. 1-7. https://doi.org/10.1186/s12906-015-0887-x.
Aghababaei, F., Hadidi, M. Recent Advances in Potential Health Benefits of Quercetin // Pharmaceuticals. – 2023. – Vol. 16. – P. 1020. https://doi.org/10.3390/ph16071020.
Marzocchella, L., Fantini, M., Benvenuto, M., Masuelli, L., Tresoldi, I., Modesti, A., Bei, R. Dietary Flavonoids: Molecular Mechanisms of Action as Anti- Inflammatory Agents. Recent Pat. Inflamm. // Allergy Drug Discov. – 2011. – Vol. 5. – P. 200-220. https://doi.org/10.2174/187221311797264937.
Carlo, G.D., Mascolo, N., Izzo, A.A., Capasso, F., Autore, G. Effects of quercetin on the gastrointestinal tract in rats and mice // Phytotherapy Research. – 1994. – Vol. 8(1). – P. 42-45. https://doi.org/10.1002/ptr.2650080110.
Konturek, S.J., Kitler, M.E., Brzozowski, T., Radecki, T. Gastric protection by merciandanol, a new synthetic flavonoid inhibiting histidine decarboxylase // Gastroenterology. – 1985. – Vol. 88. – P. 1452-7. https://doi.org/10.1007/BF01296054.
Izzo, A.A., Carlo, G.D., Mascolo, N., Capasso, F., Autore G. Antiulcer effect of flavonoids. Role of endogenous PAF // Phytotherapy Research. – 1994. – Vol. 8(3). – Vol. 179- 81. https://doi.org/10.1002/ptr.2650080313.
Hayes, N.A., Foreman, J.C. The activity of compounds extracted from feverfew on histamine release from rat mast cells // Journal of Pharmacy and Pharmacology. – 1987. – Vol. 39(6). – P. 466-70. https://doi.org/10.1111/j.2042-7158.1987.tb03421.x.
Liu, S., Tian, L., Chai, G., Wen, B., Wang, B. Targeting Heme Oxygenase-1 by Quercetin Ameliorates Alcohol-Induced Acute Liver Injury via Inhibiting NLRP3 Inflammasome Activation // Food Funct. – 2018. – Vol. 9. – P. 4184–4193. https://doi.org/10.1039/c8fo00650d.
Zhu, J.X., Wen, L., Zhong, W.J., Xiong, L., Liang, J., Wang, H.L. Quercetin, Kaempferol and Isorhamnetin in Elaeagnus Pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies // Chem. Biodivers. – 2018. – Vol. 15. – P. e1800129. https://doi.org/10.1002/cbdv.201800129.
Qin, Y., Li, Z., Chen, Y., Hui, H., Sun, Y., Yang H. III-10, a newly synthesized flavonoid, induced differentiation of human U937 leukemia cells via PKCδ activation // European Journal of Pharmaceutical Sciences. – 2012. – Vol. 45(5). – P. 648- 656. https://doi.org/10.1016/j.ejps.2012.01.004.
Tripathi, K.D. Insulin, Oral Hypoglycaemic Drugs and Glucagon. In: Essentials of medical pharmacology. 7th ed. New Delhi: JP Medical Ltd., 2013. – P. 258.
Kim, J.S., Kwon, C.S., Son, K.H. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid // Bioscience, Biotechnology and Biochemistry. – 2000. – Vol. 64(11). – P. 2458-61. https://doi.org/10.1271/bbb.64.2458.
Demonty, I., Lamarche, B., Deshaies, Y., Jacques, H. Role of soy isoflavones in the hypotriglyceridemic effect of soy protein in the rat // The Journal of Nutritional Biochemistry. – 2002. – Vol. 13(11). – P. 671-7. https://doi.org/10.1016/s0955-2863(02)00214-0.
Oboh, G., Ademosun, A.O., Ogunsuyi, O.B. Quercetin and Its Role in Chronic Diseases // Adv. Exp. Med. Biol. – 2016. – Vol. 929. – P. 377–387. https://doi.org/10.1007/978-3-319-41342-6_17.
Cheynier, V., Comte, G., Davies, K.M., Lattanzio, V., Martens, S. Plant phenolics: Recent advances on their biosynthesis, genetics and ecolphysiology // Plant Physiology and Biochemistry. – 2013. – Vol. 72. – P. 1-20. https://doi.org/10.1016/j.plaphy.2013.05.009.